Human-relevant models
Advanced 3D neuronal systems using human-derived cells to better reflect nervous system biology and disease.
3D neuronal Organ-on-Chip platform
AxCellerate combines human-derived neuronal models, glass microfluidics and non-invasive electrophysiological recording to help teams generate more predictive data before clinical development.
AxCellerate combines advanced 3D human-relevant neuronal models with functional electrophysiological readouts to support earlier, more reliable decisions in neuroscience drug development.
Our preclinical services help pharma, biotech, CROs and research institutions investigate safety, neurotoxicity, target relevance and, where suitable disease models are available, efficacy—before entering clinical development.
Advanced 3D neuronal systems using human-derived cells to better reflect nervous system biology and disease.
Direct measurement of electrical activity across complex 3D neuronal networks.
Earlier investigation of neurotoxicity, safety concerns and limited biological response.
Studies designed around each partner's scientific question, compound and development objective.
Miniaturized workflows that reduce cell and compound requirements while supporting parallel testing.
Human-relevant, non-animal preclinical approaches aligned with evolving international frameworks.
Technology overview
The platform combines 3D neuronal cultures and organoids with custom glass microfluidics and integrated microelectrode arrays.
Specialized microstructures guide neurites toward recording electrodes for non-invasive measurement.
Longitudinal electrophysiological recording tracks activity across complex 3D neuronal networks.
Tailored experimental workflows are designed around the partner’s research question, model requirements and study objectives.
From model preparation to compound testing, data acquisition and reporting, each phase is structured to support reliable preclinical decision-making.
Functional, morphological and experimental data are analysed to evaluate neuronal activity, network behaviour and biological response.
The final assessment supports investigation of safety, neurotoxicity, target relevance and, where suitable models are available, efficacy.
Our Services
AxCellerate operates through a B2B service model, supporting partners throughout the design, execution and interpretation of advanced preclinical studies.
Applications
Our current focus is the development and functional analysis of human-relevant neuronal systems for preclinical research.
Models and functional readouts supporting research into conditions such as Parkinson’s and Alzheimer’s disease.
Assessment of compound-induced effects on neuronal activity and network behaviour.
Functional characterization of dorsal forebrain, midbrain and other region-specific neuronal organoids.
Emerging applications involving spinal cord organoids and motor neuron disorders.
Advanced models for studying axonal growth, neuronal connectivity and interactions between nerves and target tissues.
Who we work with
AxCellerate works with organizations seeking more predictive and human-relevant approaches to neuroscience research.
Research Workflow
A structured service path connects scientific objectives, platform preparation, compound testing and interpretation
Publications
The AxCellerate platform originates from scientific and technological research developed through collaboration between specialists in neuroscience, microfabrication, microfluidics and pharmaceutical development.
